Eksi became involved in the late 1980s in activities to protect the secular culture of Turkey from what she perceived to be threats posed by the fundamentalist movements. She organized panels, symposiums and conferences, and organized a march of 1000 women in Caglayan, Istanbul in January 1989 to raise awareness of the dangers of fundamentalism. She collected thousands of signatures from women who supported the secular nature of the Republic of Turkey, which were presented to then President Kenan Evren. Eksi initiated, wrote and organized a number of declarations at the University of Istanbul promoting awareness of the "Core Value of the Republic of Turkey". Eksi organized teams of volunteers before the 2007, 2009 and 2011 elections, for the purpose of raising awareness of what she considered key issues of the country. Eksi and some of her colleagues, in 1989, formed Cagdas Yasimi Destekleme Dernegi where Aysel Eksi was elected as the Founding Chairwoman. She held this role until June 1990.
Publications
Eksi wrote four published books about psychiatry and was editor of the book I'm Not Ill, also about psychiatry. Eksi wrote a book containing allegations of genocide by Armenians called Armenian Genocide. Eksi was also the editor of the book Historical facts with documents and witnesses. Eksi's latest book The Youth of Turkey and Youth of Five Continents published by Nobel Books Publishing contains the results of eight years of research into adolescent psychiatry. Her research articles have been published in various international journals of science. One of the most recent published was a study of the psychological condition of children who lost relatives or loved ones in the August 1999 earthquake in the Marmara region of Turkey.
Eksi as a member of Neuropsychiatry Association, Pediatric Psychology Association, Adolescent and Pediatric Foundation and the Children's Kidney Foundation. Eksi was elected to the Board of Directors of ÇEKUL. At CEKUL, she originated and implemented the "7 Trees" programme. On the assumption that each individual consumes approximately seven trees in a year, at least seven trees are planted for each participant of the campaign. More than 2 million trees have been planted in Istanbul and its environs as a result of the programme. Eksi was elected as President of Bizim Ulke Association. This association provided primary school children living in less privileged neighbourhoods of Istanbul with summer and weekend activities and courses in sports, theatre, foreign languages, and nature. Bizim Ulke Association organised "First Aid Training Courses" for school children and the public after the August 1999 Marmara earthquake.