Barbara Nicolosi began her career in Hollywood as the Director of Project Development for in Pacific Palisades. She was hired by producer Fr. Ellwood "Bud" Kieser and worked with him for two years. She has produced five plays at the award-winning Actors Co-op Theater in Hollywood. She has worked unofficially as a script consultant for scores of feature and television projects. Officially, she was a theological consultant on Saving Grace and for The Passion of the Christ. Nicolosi began her professional writing career as a media columnist for the Catholic monthly magazine . In 2004, she moved her column to the National Catholic Register newspaper and the on-line site CatholicExchange.com. She won Catholic Press Awards for her media columns in 2002 and 2004. One of her columns was selected for the 2006 Loyola Press release, . She is the co-editor of the 2006 Baker Books release, Behind the Screen: Hollywood Insiders on Faith and Culture. She co-authored the 2016 book Notes to Screenwriters for Michael Wiese Books. Nicolosi has served as a judge or jurist on many cinema and arts panels. She was a grants panelist for the National Endowment for the Arts, on the film jury for the Catholics in Media Awards, a judge for the Catholic Academy's Gabriel Awards, a reader for the Humanitas Prize for screenwriting, and served for nearly ten years on the Blue Ribbon Jury of the Angelus Awards, student film festival. She won several awards for her work including the Legatus Outstanding Laity Award, the Spirit Award of the Windrider Forum at Sundance, the Act One Servant Faculty Award, and special awards for her contributions to cinema studies from the Catholic University of Valencia, Spain, and Santa Croce University. Nicolosi has taught screenwriting or cinema studies as an adjunct professor in the Seaver Graduate School at Pepperdine University, and also in undergraduate programs at Azusa Pacific University and the Los Angeles Film Study Center. She has been a guest lecturer on art and cinema at many other institutions of higher learning including Notre Dame University ; Gonzaga University, Biola University, Ave Maria University, Santa Croce University, the Catholic University and the Catholic University of Valencia. She was also a featured speaker at events hosted by the United States Catholic Conference of Bishops, and for the Pontifical Council for Culture at the Vatican. In 2015, Nicolosi accepted a position at Azusa Pacific University as an Associate Professor in the newly formed Honors College. Nicolosi is President of Catharsis: The Story Lab, a mentorship and out-sourced development program for visual storytellers. She was founder and Chair Emeritus of Act One, Inc., a Christian organization for training aspiring scriptwriters and producers starting out in Hollywood. She was also a founding partner in Origin Entertainment. She is a member of the Writers Guild of America, West. She co-wrote Mary Mother of the Christ with Benedict Fitzgerald. She wrote Fatima, for Origin Entertainment.