In 1992, after 16 years as an elected official in Lawrence County, Skillman was elected to the Indiana State Senate, where she represented all or part of Lawrence, Monroe, Jackson, Washington, and Orange Counties. Rising quickly through the leadership, she became Majority Caucus Chair, the first woman in history to serve in the Senate Republican leadership. During her 12 years in the Senate, she led the charge to include the state's small towns and rural communities in its economic development agenda. There, she authored plans for development in distressed counties and for the revitalization of downtown areas.
Lieutenant governor
selected Skillman to be his running mate during the 2004 election. The ticket was elected over incumbent Governor Joe Kernan and incumbent Lieutenant GovernorKathy Davis and she took office in January. As Indiana's 49th Lt. Governor, Skillman held more legal duties than any other Lt. Governor in the country. Upon taking office in 2005, Skillman also served as the Secretary of Agriculture and Rural Development under the state's Department of Agriculture and Office of Community Rural Affairs. She managed five state agencies in total, and administered more than $1 billion in programs. Other agencies under Skillman's direction as Lt. Governor included the Office of Energy Development, the Indiana Housing and Community Development Authority, and the Office of Tourism Development. Additionally, she chaired the state's Counter Terrorism and Security Council, the intergovernmental entity responsible for homeland security, and served as President of the Indiana Senate. Skillman was also responsible for shepherding Governor Mitch Daniels's Administration's legislative agenda through the Indiana General Assembly and served as President of the Senate.
Radius Indiana
Skillman currently serves as Chair of the Board of Directors of Radius Indiana, an eight-county economic development corporation in South Central Indiana. Prior to accepting the board chair position in 2017, she served as president and CEO, beginning in February 2013; during her tenure, Radius rose in prominence among economic development organizations in the state. She also served as the co-chair of the Indiana Bicentennial Commission, with former U.S. Congressman Lee Hamilton.
2012 election
Skillman had considered a run for Indiana Governor in 2012 but announced she would not due to a minor medical condition.