Bondi was born in Chicago, Illinois, the daughter of Eva Suzanna, an author, and Abraham O. Bondy, who worked in real estate. The family moved to Valparaiso, Indiana when she was three, and Bondi began her acting career on the stage at age seven, playing Cedric Errol in a production of Little Lord Fauntleroy at the Memorial Opera House in Valparaiso. She graduated from the Frances Shimer Academy in 1907, and gained her bachelor's and master's degrees in oratory at Valparaiso University in 1916 and 1918. She made her Broadway debut in Kenneth Seymour Webb's One of the Family at the 49th Street Theatre on December 21, 1925. She next appeared in another hit, Maxwell Anderson's Saturday's Children, in 1926. It was Bondi's performance in Elmer Rice's Pulitzer Prize-winning Street Scene, which opened at the Playhouse Theatre on January 10, 1929, that brought Bondi to the movies at the age of 43. Her debut movie role was as "Emma Jones" in Street Scene, which starred Sylvia Sidney, and in which Bondi reprised her stage role, followed by "Mrs. Davidson" in Rain, which starred Joan Crawford and Walter Huston. She was one of the first five women to be nominated for an Academy Award in the newly created category of "Best Supporting Actress" for her work in The Gorgeous Hussy, although she lost the award to Gale Sondergaard. Two years later she was nominated again for Of Human Hearts and lost again, but her reputation as a character actress kept her employed. She would most often be seen in the role of the mother of the star of the film for the rest of her career, with the exception of Make Way for Tomorrow as the abandoned Depression-era 'Ma' Cooper. She often played mature roles in her early film career even though she was only in her early 40s. In 1940 Bondi played Mrs. Webb in Our Town and Granny Tucker in The Southerner, directed by Jean Renoir and released in 1945. For her contributions to the film industry, Bondi received a motion pictures star on the Hollywood Walk of Fame in 1960. The star is located at 1718 Vine Street.
Television
Bondi's television credits include Alfred Hitchcock Presents and Howard Richardson's Ark of Safety on the Goodyear Television Playhouse. She appeared with Jan Clayton in "The Prairie Story" on NBC's Wagon Train.. She made a guest appearance on Perry Mason in 1963 when she played the role of Sophia Stone in "The Case of the Nebulous Nephew." Bondi made her final appearances as Martha Corinne Walton on The Waltons in the episodes "The Conflict" and "The Pony Cart". She received an Emmy award for Outstanding Lead Actress for a Single Appearance in a Drama or Comedy Series for her performance in "The Pony Cart", her final career screen performance. When her name was called, it first appeared that she was not present, but she received a standing ovation as she walked slowly to the podium, from which she thanked the audience for honoring her while she was still living.