Billboard Year-End Hot 100 singles of 2000
This is a list of Billboard magazine's Top Hot 100 songs of 2000.
| No. | Title | Artist |
| 1 | "Breathe" | Faith Hill |
| 2 | "Smooth" | Santana featuring Rob Thomas |
| 3 | "Maria Maria" | Santana featuring The Product G&B |
| 4 | "I Wanna Know" | Joe |
| 5 | "Everything You Want" | Vertical Horizon |
| 6 | "Say My Name" | Destiny's Child |
| 7 | "I Knew I Loved You" | Savage Garden |
| 8 | "Amazed" | Lonestar |
| 9 | "Bent" | Matchbox Twenty |
| 10 | "He Wasn't Man Enough" | Toni Braxton |
| 11 | "Higher" | Creed |
| 12 | "Try Again" | Aaliyah |
| 13 | "Jumpin', Jumpin'" | Destiny's Child |
| 14 | "Thong Song" | Sisqó |
| 15 | "Kryptonite" | 3 Doors Down |
| 16 | "There You Go" | Pink |
| 17 | "Music" | Madonna |
| 18 | "Doesn't Really Matter" | Janet Jackson |
| 19 | "What a Girl Wants" | Christina Aguilera |
| 20 | "Back at One" | Brian McKnight |
| 21 | "Bye Bye Bye" | 'N Sync |
| 22 | "You Sang to Me" | Marc Anthony |
| 23 | "I Need to Know" | Marc Anthony |
| 24 | "Get It On Tonite" | Montell Jordan |
| 25 | "Incomplete" | Sisqó |
| 26 | "I Try" | Macy Gray |
| 27 | "It's Gonna Be Me" | 'N Sync |
| 28 | "That's The Way It Is" | Celine Dion |
| 29 | "Country Grammar " | Nelly |
| 30 | "Bring It All to Me" | Blaque |
| 31 | "Show Me the Meaning of Being Lonely" | Backstreet Boys |
| 32 | "Hot Boyz" | Missy Elliott featuring Nas, Eve and Q-Tip |
| 33 | "Back Here" | BBMak |
| 34 | "It Feels So Good" | Sonique |
| 35 | "Absolutely " | Nine Days |
| 36 | "With Arms Wide Open" | Creed |
| 37 | "Be with You" | Enrique Iglesias |
| 38 | "Come On Over Baby " | Christina Aguilera |
| 39 | "No More" | Ruff Endz |
| 40 | "All The Small Things" | Blink 182 |
| 41 | "The Way You Love Me" | Faith Hill |
| 42 | "I Turn To You" | Christina Aguilera |
| 43 | "Never Let You Go" | Third Eye Blind |
| 44 | "I Need You" | LeAnn Rimes |
| 45 | "Thank God I Found You" | Mariah Carey featuring Joe and 98 Degrees |
| 46 | "Let's Get Married" | Jagged Edge |
| 47 | "My Love Is Your Love" | Whitney Houston |
| 48 | "Then The Morning Comes" | Smash Mouth |
| 49 | "Blue " | Eiffel 65 |
| 50 | "Desert Rose" | Sting featuring Cheb Mami |
| 51 | "The Real Slim Shady" | Eminem |
| 52 | "Most Girls" | Pink |
| 53 | "Wifey" | Next |
| 54 | "Wonderful" | Everclear |
| 55 | "Oops!... I Did It Again" | Britney Spears |
| 56 | "I Wanna Love You Forever" | Jessica Simpson |
| 57 | "Give Me Just One Night " | 98 Degrees |
| 58 | "Take a Picture" | Filter |
| 59 | "Otherside" | Red Hot Chili Peppers |
| 60 | "Big Pimpin'" | Jay-Z featuring UGK |
| 61 | "A Puro Dolor" | Son by Four |
| 62 | "He Can't Love U" | Jagged Edge |
| 63 | "Separated" | Avant |
| 64 | "I Wish" | Carl Thomas |
| 65 | "U Know What's Up" | Donell Jones |
| 66 | "Faded" | soulDecision featuring Thrust |
| 67 | "Only God Knows Why" | Kid Rock |
| 68 | "Shake Ya Ass" | Mystikal |
| 69 | "Bag Lady" | Erykah Badu |
| 70 | "Meet Virginia" | Train |
| 71 | "Party Up " | DMX |
| 72 | "Case of the Ex" | Mýa |
| 73 | "Forgot About Dre" | Dr. Dre featuring Eminem |
| 74 | "That's the Way" | Jo Dee Messina |
| 75 | "Swear It Again" | Westlife |
| 76 | "The Next Episode" | Dr. Dre featuring Snoop Dogg |
| 77 | "From the Bottom of My Broken Heart" | Britney Spears |
| 78 | "Crash and Burn" | Savage Garden |
| 79 | "Yes!" | Chad Brock |
| 80 | "The Best Day" | George Strait |
| 81 | "Where I Wanna Be" | Donell Jones |
| 82 | "How Do You Like Me Now?!" | Toby Keith |
| 83 | "My Best Friend" | Tim McGraw |
| 84 | "Broadway" | Goo Goo Dolls |
| 85 | "What'chu Like" | Da Brat featuring Tyrese |
| 86 | "Don't Think I'm Not" | Kandi |
| 87 | "I Hope You Dance" | Lee Ann Womack |
| 88 | "Better Off Alone" | Alice Deejay |
| 89 | "Dance with Me" | Debelah Morgan |
| 90 | "What About Now" | Lonestar |
| 91 | "I Like It" | Sammie |
| 92 | "24/7" | Kevon Edmonds |
| 93 | "Girl on TV" | LFO |
| 94 | "Bounce with Me" | Lil' Bow Wow featuring Xscape |
| 95 | "Cowboy Take Me Away" | Dixie Chicks |
| 96 | "I Don't Wanna" | Aaliyah |
| 97 | "Independent Women" | Destiny's Child |
| 98 | "Gotta Tell You" | Samantha Mumba |
| 99 | "Waiting for Tonight" | Jennifer Lopez |
| 100 | "Shackles " | Mary Mary |