Billboard Year-End Hot 100 singles of 2010
Billboard publishes annual lists of songs based on chart performance over the course of a year based on Nielsen Broadcast Data Systems and SoundScan information. For 2010, the list for the top 100 Billboard Hot 100 Year-End songs was published on December 8, calculated with data from December 5, 2009 to November 27, 2010. At the number-one position was Kesha's "Tik Tok", which stayed atop the Hot 100 for nine weeks. This achievement made her the first female in the history of the chart to top the Year-End Hot 100 with a debut single.
| No. | Title | Artist |
| 1 | "Tik Tok" | Kesha |
| 2 | "Need You Now" | Lady Antebellum |
| 3 | "Hey, Soul Sister" | Train |
| 4 | "California Gurls" | Katy Perry featuring Snoop Dogg |
| 5 | "OMG" | Usher featuring will.i.am |
| 6 | "Airplanes" | B.o.B featuring Hayley Williams |
| 7 | "Love the Way You Lie" | Eminem featuring Rihanna |
| 8 | "Bad Romance" | Lady Gaga |
| 9 | "Dynamite" | Taio Cruz |
| 10 | "Break Your Heart" | Taio Cruz featuring Ludacris |
| 11 | "Nothin' on You" | B.o.B featuring Bruno Mars |
| 12 | "I Like It" | Enrique Iglesias featuring Pitbull |
| 13 | "BedRock" | Young Money featuring Lloyd |
| 14 | "In My Head" | Jason Derulo |
| 15 | "Rude Boy" | Rihanna |
| 16 | "Telephone" | Lady Gaga featuring Beyoncé |
| 17 | "Teenage Dream" | Katy Perry |
| 18 | "Just the Way You Are" | Bruno Mars |
| 19 | "Cooler Than Me" | Mike Posner |
| 20 | "Imma Be" | The Black Eyed Peas |
| 21 | "Empire State of Mind" | Jay-Z featuring Alicia Keys |
| 22 | "DJ Got Us Fallin' in Love" | Usher featuring Pitbull |
| 23 | "Billionaire" | Travie McCoy featuring Bruno Mars |
| 24 | "Not Afraid" | Eminem |
| 25 | "Replay" | Iyaz |
| 26 | "Sexy Bitch" | David Guetta featuring Akon |
| 27 | "Breakeven" | The Script |
| 28 | "Your Love Is My Drug" | Kesha |
| 29 | "I Gotta Feeling" | The Black Eyed Peas |
| 30 | "Fireflies" | Owl City |
| 31 | "Say Aah" | Trey Songz featuring Fabolous |
| 32 | "Find Your Love" | Drake |
| 33 | "Alejandro" | Lady Gaga |
| 34 | "Ridin' Solo" | Jason Derulo |
| 35 | "Just a Dream" | Nelly |
| 36 | "How Low" | Ludacris |
| 37 | "Like a G6" | Far East Movement featuring The Cataracs and Dev |
| 38 | "Carry Out" | Timbaland featuring Justin Timberlake |
| 39 | "Haven't Met You Yet" | Michael Bublé |
| 40 | "Club Can't Handle Me" | Flo Rida featuring David Guetta |
| 41 | "Down" | Jay Sean featuring Lil Wayne |
| 42 | "Bulletproof" | La Roux |
| 43 | "Whatcha Say" | Jason Derulo |
| 44 | "Baby" | Justin Bieber featuring Ludacris |
| 45 | "Whataya Want from Me" | Adam Lambert |
| 46 | "Mine" | Taylor Swift |
| 47 | "Only Girl " | Rihanna |
| 48 | "Live Like We're Dying" | Kris Allen |
| 49 | "Hard" | Rihanna featuring Jeezy |
| 50 | "Young Forever" | Jay-Z featuring Mr Hudson |
| 51 | "Blah Blah Blah" | Kesha featuring 3OH!3 |
| 52 | "Bottoms Up" | Trey Songz featuring Nicki Minaj |
| 53 | "Do You Remember" | Jay Sean featuring Sean Paul and Lil Jon |
| 54 | "All the Right Moves" | OneRepublic |
| 55 | "According to You" | Orianthi |
| 56 | "My Chick Bad" | Ludacris featuring Nicki Minaj |
| 57 | "You Belong with Me" | Taylor Swift |
| 58 | "Meet Me Halfway" | The Black Eyed Peas |
| 59 | "Take It Off" | Kesha |
| 60 | "Over" | Drake |
| 61 | "Animal" | Neon Trees |
| 62 | "Misery" | Maroon 5 |
| 63 | "Magic" | B.o.B featuring Rivers Cuomo |
| 64 | "Paparazzi" | Lady Gaga |
| 65 | "Tie Me Down" | New Boyz featuring Ray J |
| 66 | "Your Love" | Nicki Minaj |
| 67 | "Party in the U.S.A." | Miley Cyrus |
| 68 | "Deuces" | Chris Brown featuring Tyga and Kevin McCall |
| 69 | "3" | Britney Spears |
| 70 | "Impossible" | Shontelle |
| 71 | "Forever" | Drake featuring Kanye West, Lil Wayne and Eminem |
| 72 | "Two Is Better Than One" | Boys Like Girls featuring Taylor Swift |
| 73 | "My First Kiss" | 3OH!3 featuring Kesha |
| 74 | "Already Gone" | Kelly Clarkson |
| 75 | "Rock That Body" | The Black Eyed Peas |
| 76 | "Secrets" | OneRepublic |
| 77 | "Naturally" | Selena Gomez & the Scene |
| 78 | "Un-Thinkable " | Alicia Keys |
| 79 | "All I Do Is Win" | DJ Khaled featuring T-Pain, Ludacris, Snoop Dogg and Rick Ross |
| 80 | "I Made It " | Kevin Rudolf featuring Birdman, Jay Sean and Lil Wayne |
| 81 | "Stuck Like Glue" | Sugarland |
| 82 | "Hey Daddy " | Usher featuring Plies |
| 83 | "There Goes My Baby" | Usher |
| 84 | "Today Was a Fairytale" | Taylor Swift |
| 85 | "Say Something" | Timbaland featuring Drake |
| 86 | "Sweet Dreams" | Beyoncé |
| 87 | "Use Somebody" | Kings of Leon |
| 88 | "Undo It" | Carrie Underwood |
| 89 | "Eenie Meenie" | Sean Kingston and Justin Bieber |
| 90 | "Right Above It" | Lil Wayne featuring Drake |
| 91 | "The House That Built Me" | Miranda Lambert |
| 92 | "If I Die Young" | The Band Perry |
| 93 | "The Only Exception" | Paramore |
| 94 | "American Honey" | Lady Antebellum |
| 95 | "King of Anything" | Sara Bareilles |
| 96 | "Life After You" | Daughtry |
| 97 | "Smile" | Uncle Kracker |
| 98 | "Teach Me How to Dougie" | Cali Swag District |
| 99 | "Try Sleeping with a Broken Heart" | Alicia Keys |
| 100 | "Lover, Lover" | Jerrod Niemann |