A pre-engineering program called Project Lead The Way is offered to students who are interested. It includes such courses as Computer Integrated Manufacturing Systems and Engineering Design and Development. This is made possible through a partnership between the school and Rochester Institute of Technology. These courses allow students interested in going into an engineering field an opportunity to earn college credits and eliminate beginner courses in college.
The Rod Serling School of Fine Arts offers the opportunity to major in visual art, music, theater and dance. Each of these programs have a wide array of groups and talented individuals that regularly perform for the community. Most of these programs are also offered at the IB level. The school is named after the screenwriter and creator of The Twilight Zone series, Rod Serling, who is a graduate of Binghamton High School. The Helen Foley Theater, part of the school, is named after Serling's former teacher. The school hosts the annual Rod Serling Film Festival, which is open to all students in grades K-12 in North America.
Athletics
Binghamton High School offers many programs for athletics, including men's and women's basketball teams and also a football team. Binghamton High competes in the STAC conference for most sports, with the exception of football, which competes in Section 4 Class AA.
Football
The football team at Binghamton High School has won several titles since their first season in 1981, including the Section 4 title in 1985, 1987, 1991, 1992, 1993, 2004, 2008, 2011, 2012, 2016 and Central Region titles in 2008 and 2011. The team also won a New York State title in 1985.
Basketball
The boys' and girls' basketball teams have also won titles. The boys' team won back to back state titles in the 1984-85 and 1985-1986 seasons. The women's team has done well in recent years, winning both conference and sectional titles in the 2009-10, 2010–11, and 2011–2012 seasons. In 2011-2012, both the boys' and girls' teams won at least 20 games, including conference and sectional titles, to enter the State Playoffs with undefeated records.
Track and Field
The boys' track & field team won a divisional title in 2011.
Baseball
Won Division titles in 1985, 1987, 1998, and 2005. Section 4 titles in 1985 and 1987.
Recognitions
On the Newsweek's list of the "Best High Schools in America" for 2007, Binghamton High School was ranked #481 out of approximately 1,200 top high schools in the United States, based on the number of participants in AP and IB courses. Binghamton High School has one of very few high school-level steel drum bands in the United States. Along with the musical aspect of the school's arts programs, the school puts on a selected play and full-scale musical every year. Theater Production Club builds the sets and operates the show while anyone from the student body can try out for roles.
