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Buthionine sulfoximine
Buthionine
sulfoximine
is a sulfoximine which
reduces
levels
of
glutathione
and is being investigated as an
adjunct
with
chemotherapy
in the
treatment of cancer
.
The compound
inhibits
gamma-glutamylcysteine synthetase
, the
enzyme
required
in the first
step
of
glutathione synthesis
. Buthionine sulfoximine may also be used to
increase
the
sensitivity
of
parasites
to
oxidative
antiparasitic drugs
.
