C-type lectin


A C-type lectin is a type of carbohydrate-binding protein domain known as a lectin. The C-type designation is from their requirement for calcium for binding. Proteins that contain C-type lectin domains have a diverse range of functions including cell-cell adhesion, immune response to pathogens and apoptosis.

Classification

Drickamer et al. classified C-type lectins into 7 subgroups based on the order of the various protein domains in each protein. This classification was subsequently updated in 2002, leading to seven additional groups. Most recently, three further subgroups were added.
GroupNameAssociated domains
ILecticansEGF, Sushi, Ig and Link domains
IIAsialoglycoprotein and DC receptors-
IIICollectins-
IVSelectinsSushi and EGF domains
VNK - cell receptors-
VIMulti-CTLD endocytic receptorsFnII and Ricin domains
VIIReg group-
VIIIChondrolectin, Layilin-
IXTetranectin-
XPolycystinWSC, REJ, PKD domains
XIAttractin PSI, EGF and CUB domains
XIIEosinophil major basic protein -
XIIIDGCR2-
XIVThrombomodulin, CD93, CD248, CLEC14AEGF domains
XVBimlec-
XVISEECSCP and EGF domains
XVIICBCP/Frem1/QBRICKCSPG repeats and CalX-beta domains

CLECs include:
The "NK Cell lectin-like receptors" are a very closely related group:
Additional proteins containing this domain include: