After redshirting his first year at Notre Dame in 2012, Prosise played in all 13 games as a wide receiver and on special teams his redshirt freshman year in 2013. For the season, he had seven receptions for 72 yards. As a sophomore in 2014, he played in all 13 games and made six starts. He had 29 receptions for 516 yards and two touchdowns and led the team in special teams tackles with 11. Prior to his junior year in 2015, Prosise was moved to running back. After a season-ending injury to Tarean Folston versus Texas, Prosise became the starter. In his first start against Virginia, he rushed for 155 yards with a touchdown. In his second start against Georgia Tech, he rushed for 198 yards and three touchdowns, including a 91-yard rushing touchdown which was the longest in Notre Dame Stadium history. Prosise continued adding big performances throughout the season. He recorded 100 receiving yards at Clemson, rushed for 129 yards and three touchdowns against Navy, and rushed for 143 yards and two touchdowns against USC, before being slowed down by injury, limited him to only 13 carries over Notre Dame's last five games. He finished the season rushing for 1,032 yards on 156 carries and 11 touchdowns, and 28 receptions for 308 yards and one touchdown. Following Notre Dame's loss against Ohio State in the Fiesta Bowl, Prosise announced he would forego his remaining eligibility and enter the 2016 NFL Draft.
Professional career
Prosise was drafted by the Seattle Seahawks in the third round of the 2016 NFL Draft. On May 6, 2016, the Seahawks signed Prosise to a four-year, $3.11 million contract with a signing bonus of $692,464. Prosise started his first game against the New England Patriots in Week 10, where he carried the ball 17 times for 66 yards and added 87 receiving yards in the win. Prosise also started the Week 11 game against the Philadelphia Eagles and scored his first career touchdown, a 72-yard run, but suffered a fractured scapula that ended his rookie season. On November 14, 2017, Prosise was placed on injured reserve with an ankle injury. He finished his second season with 23 rushing yards, and 6 receptions for 87 yards during his injury-riddled season. In 2018, Prosise played in five games before being placed on injured reserve with abdomen, groin, and hip-flexor injuries. In 2019, Prosise played in nine games, recording 72 rushing yards and a touchdown along with 10 receptions for 76 yards. He suffered a broken arm in Week 16 and was placed on injured reserve on December 24, 2019.
