CD180
CD180 antigen is a protein that in humans is encoded by the CD180 gene.
CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats and a short cytoplasmic tail. It is also known by the archaic terms Bgp-95 and RP105, for the founding designations following discovery in humans and mice, respectively. CD180 is expressed on antigen presenting cells including B cells and dendritic cells. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, CD180/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors. CD180/MD-1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide, a membrane constituent of Gram-negative bacteria.
Recently, CD180 has been demonstrated to be involved in the survival and prognosis of B-cell chronic lymphocytic leukemia.
