CD27


CD27 is a member of the tumor necrosis factor receptor superfamily. It is currently of interest to immunologists as a co-stimulatory immune checkpoint molecule.

Function

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-κB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein, a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor.
In murine γδ T cells its expression has been correlated with the secretion of IFNγ.

Clinical significance

As a drug target

is an antibody that binds to CD27 and is an experimental cancer treatment.

Interactions

CD27 has been shown to interact with SIVA1, TRAF2 and TRAF3.