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CD98
CD98
is a
glycoprotein
that is a
heterodimer
composed of
SLC3A2
and
SLC7A5
that forms the
large
neutral amino acid transporter
. LAT1 is a heterodimeric
membrane transport protein
that preferentially transports
branched-chain
and
aromatic amino acids
. LAT is highly expressed in
brain
capillaries
relative
to other
tissues
.
A
functional
LAT1
transporter
is
composed
of two
proteins
encoded by two
distinct
genes:
4F2hc/CD98 heavy
subunit protein
encoded by the SLC3A2 gene
CD98
light
subunit
protein
encoded by the SLC7A5 gene