CIZ1


Cip1-interacting zinc finger protein is a protein that in humans is encoded by the CIZ1 gene.

Function

The protein encoded by this gene is a zinc finger DNA binding transcription factor that interacts with CIP1, part of a complex with cyclin E. The encoded protein may regulate the cellular localization of CIP1.

Clinical significance

An altered circulating form of the Ciz1 protein is synthesized by lung cancer cells, even when they are at a very early stage. Hence detection of this protein variant in blood could be used as a biomarker for early detection of lung cancer.

Interactions

CIZ1 has been shown to interact with P21.