CRKL
Crk-like protein is a protein that in humans is encoded by the CRKL gene.Function
v-CRK avian sarcoma virus CT10-homolog-like contains one SH2 domain and two SH3 domains. CRKL has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase and plays a role in fibroblast transformation by BCR-ABL. In addition, CRKL has oncogenic potential.
CrkL together with Crk participates in the Reelin signaling cascade downstream of DAB1.Interactions
CRKL has been shown to interact with:
- Abl gene,
- BCAR1,
- BCR gene,
- CBLB,
- CD117,
- CD34,
- Cbl gene,
- Dock2,
- EPOR,
- GAB1,
- GAB2,
- INPP5D,
- MAP4K1,
- MAP4K5,
- NEDD9,
- PIK3R2,
- Paxillin
- RAPGEF1,
- RICS,
- STAT5A,
- Syk, and
- WAS.
