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CSTF2
Cleavage stimulation factor
64
kDa
subunit
is a
protein
that in
humans
is
encoded
by the
CSTF2
gene
.
This gene encodes a
nuclear protein
with an
RRM
domain
. The protein is a member of the
cleavage stimulation factor
complex
that is
involved
in the
3' end
cleavage
and
polyadenylation
of pre-mRNAs.
Specifically
, this protein
binds
GU-rich
elements
within the
3'-untranslated region
of mRNAs.
Interactions
CSTF2 has been
shown
to
interact
with
CSTF3
,
SUB1
,
SYMPK
,
BARD1
and
BRCA1
.