Born in Visalia, California, he grew up on his parents' farm several miles east of Hanford and graduated from Hanford Union High School in 1972. Dooley earned his bachelor's degree in agricultural economics from the University of California, Davis in 1977 and a master's degree in Management from Stanford University in 1987. Dooley worked as a rancher and then as an administrative assistant for California State SenatorRose Ann Vuich from 1987 to 1990. In mid-1990, Dooley won the Democratic primary for what was then the 17th District and faced six-term RepublicanChip Pashayan in November. Although Pashayan had been reelected with 71 percent of the vote in 1988, he was bogged down by the House banking scandal, and Dooley defeated him by just over 9 points. In 1992, his district was renumbered as the 20th District and drawn as a Latino-majority district. He was easily reelected that year and five more times after that. He faced only one truly serious contest, when Republican Rich Rodriguez managed to hold him to 53 percent of the vote. A "New Democrat," his voting record was considered moderate, as is typical for Democrats from the Central Valley. Dooley announced his retirement in 2004 and endorsed his Chief of Staff, Lisa Quigley, as his successor. However, most of the rest of the state Democratic establishment endorsed Jim Costa, a former state legislator from the Fresno area. This touched off a contentious primary battle which was won by Costa, all but assuring him of victory in November. On October 10, 2002, Cal Dooley was among the 81 House Democrats who voted in favor of authorizing the invasion of Iraq. He has later said that he regrets this vote. Having served as the President and CEO of the Food Products Association, Dooley assumed the same roles at the Grocery Manufacturers Association, following a merger with the FPA. GMA is a Washington-based trade association representing food manufacturers. In September 2008, Dooley assumed the position of CEO of the American Chemistry Council, the trade association for American chemical companies. He announced his retirement in 2018. Dooley is married to the former Linda Phillips, who heads the Bryce Harlow Foundation in Washington DC. The couple has two daughters, Brooke Ybarra, who works for the federal government, and Emily Dooley, a realtor in Charlottesville, Virginia.