Calcium-induced calcium release


Calcium-induced calcium release describes a biological process whereby calcium is able to activate calcium release from intracellular Ca2+ stores. Although CICR was first proposed for skeletal muscle in the 1970s, it is now known that CICR is unlikely to be the primary mechanism for activating SR calcium release. Instead, CICR is thought to be crucial for excitation-contraction coupling in cardiac muscle and it is now obvious that CICR is a widely occurring cellular signaling process present even in many non-muscle cells, e.g. in the insulin-secreting pancreatic beta cells and many other cells. Since CICR is a positive-feedback system, it has been of great interest to elucidate the mechanism responsible for its termination.

Examples in biology

Excitation-contraction coupling

in myocardium relies on sarcolemma depolarization and subsequent Ca2+ entry to trigger Ca2+ release from the sarcoplasmic reticulum. When an action potential depolarizes the cell membrane, voltage-gated Ca2+ channels are activated. CICR occurs when the resulting Ca2+ influx activates ryanodine receptors on the SR membrane, which causes more Ca2+ to be released into the cytosol. In cardiac muscle, the result of CICR is observed as a spatio-temporally restricted Ca2+ spark. The result of CICR across the cell causes the significant increase in cytosolic Ca2+ that is important in activating muscle contraction.