Murigande was born in Butare, Rwanda. In 1960 following the civil strife that preceded Rwanda's independence, his family fled to Burundi, where he grew up as refugee. He did his primary, secondary and part of his university education in Burundi. He did his graduate and post-graduate studies in Belgium where he obtained in 1986, a Ph.D in Mathematics from the Facultés Universitaires Notre Dame de la Paix, in Namur.
Career
From 1986 to 1988 he worked as a scientific adviser to the Director General of the Geographical Institute of Burundi and was at the same time Head of the Computing Center of the Institute. He joined Howard University, Washington D.C., U.S.A in January 1989 as a Post-doctoral fellow, where he later became an Assistant Professor and Head of the Biostatistical Division of College of Medicine. Following the 1994 genocide in Rwanda which claimed about one million lives, Murigande abandoned his academic career at Howard University and went back to Rwanda to contribute to the reconstruction of his country. During the Rwandan Civil War, he was the Spokesperson of the Rwandan Patriotic Front in the United States. Since 1994, Murigande has served in the following positions:
From September 1994 to August 1995, Adviser to the President on Foreign Affairs
Murigande was elected Secretary General of the Rwandan Patriotic Front on February 15, 1998 and was reelected on December 23, 2002
On November 15, 2002, Murigande became Minister of Foreign Affairs and Regional Cooperation
After more than five years as Foreign Minister, Murigande was moved to the position of Minister of Governmental Affairs in the government named on March 8, 2008. He was moved to the post of Minister of Education on July 26, 2009. Murigande was Minister of Education for nearly two years before being replaced by Pierre Habumuremyi in May 2011. He was then appointed as Ambassador to Japan. He presented his credentials to Emperor Akihito on 4 October 2011. During his academic life, Murigande has published several papers in international peer-reviewed Scientific Journals.