The Worshipful Society of Apothecaries initially established the garden on a leased site of Sir John Danvers' well-established garden in Chelsea, London. This house, called Danvers House, adjoined the mansion that had once been the house of Sir Thomas More. Danvers House was pulled down in 1696 to make room for Danvers Street. In 1713, Dr Hans Sloane purchased from Charles Cheyne the adjacent Manor of Chelsea, about, which he leased in 1722 to the Society of Apothecaries for £5 a year in perpetuity, requiring only that the Garden supply the Royal Society, of which he was a principal, with 50 good herbarium samples per year, up to a total of 2,000 plants. That initiated the golden age of the Chelsea Physic Garden under the direction of Philip Miller, when it became the world's most richly stocked botanic garden. Its seed-exchange programme was established following a visit in 1682 from Paul Hermann, a Dutch botanist connected with the Hortus Botanicus Leiden and has lasted till the present day. The seed exchange program's most notable act may have been the introduction of cotton into the colony of Georgia and more recently, the worldwide spread of the Madagascar Periwinkle. Isaac Rand, a member and a fellow of the Royal Society published a condensed catalogue of the Garden in 1730, Index plantarum officinalium, quas ad materiae medicae scientiam promovendam, in horto Chelseiano. Elizabeth Blackwell's A Curious Herbal was illustrated partly from specimens taken from the Chelsea Physic Garden. Sir Joseph Banks worked with the head gardener and curator John Fairbairn during the 1780–1814 period. Fairbairn specialized in growing and cultivating plants from around the world. Parts of this classic garden have been lost to road development – the river bank during 1874 construction of the Chelsea Embankment on the north bank of the River Thames, and a strip of the garden to allow widening of Royal Hospital Road. What remains is a patch in the heart of London. As of 2020, the chairman of the trust that manages the garden is Michael Prideaux. The garden Director is Sue Medway. As of 2019 the Garden is raising funds to restore the historic glasses on the site.
Current garden
As of October 2017, the garden included 5,000 plants, in areas such as:
The Garden of Medicinal Plants
The Pharmaceutical Garden, with plants arranged according to the ailment they are used to treat
The Garden of World Medicine, with medicinal plants arranged by the culture which uses them