Cholecystokinin receptor
Cholecystokinin receptors or CCK receptors are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin and gastrin. There are two different subtypes CCKA and CCKB which are ~50% homologous: Various cholecystokinin antagonists have been developed and are used in research, although the only drug of this class that has been widely marketed to date is the anti-ulcer drug proglumide.
| protein | gene | tissue distribution | preferred ligand | function |
| CCKA | primarily gastrointestinal tract, lesser amounts in the CNS | sulfated CCK >> nonsulfated CCK ≈ nonsulfated CCK | stimulation of bicarb secretion, gall bladder emptying and inhibiting gut motility | |
| CCKB | primarily CNS, lesser amounts in the gastrointestinal tract | gastrin ≈ CCK | regulation of nociception, anxiety, memory and hunger |