Van Zeyl was drafted in the third round with the 18th overall pick in the 2007 CFL Draft by the Montreal Alouettes and attended training camp with the Alouettes but returned to McMaster in August. He noted that the Alouettes intention was for him to remain as a defensive lineman as a professional player, which was his preferred position. He re-joined Montreal in October and remained on the practice roster for the remainder of the 2007 Montreal Alouettes season. Van Zeyl attended the 2008 Montreal Alouettes training camp and was again added to the practice roster but was released on September 3, 2008.
Toronto Argonauts
On September 5, 2008, Van Zeyl signed with the Toronto Argonauts as a free agent and was assigned to the Argos practice roster. He was converted to the offensive side of the ball as an offensive lineman and remained on the practice roster for the rest of the year. He re-signed with Toronto on December 3, 2008 for the 2009 Toronto Argonauts season but was released at the end of training camp. He was re-signed to the practice roster on June 27, 2009. He was signed to the active roster on August 27 and dressed in his first professional regular season game on August 28, 2009 in a loss to the Calgary Stampeders. He got his first playing opportunity on October 16, 2009, when starting right tackle, Brian Ramsay, suffered an injury and Van Zeyl was pressed into action. He started his first professional game on October 23, 2009 against the Hamilton Tiger-Cats as well as the last two games of the season. In 2010, Van Zeyl entered the season as the team's starting right offensive tackle and played in 14 regular season games, missing four due to injury. He recorded his first career reception on a 10-yard pass from Cleo Lemon in the Labour Day Classic on September 6, 2010, but was injured on the play and had to sit out the next game. He started at right tackle in both playoff games for the Argonauts that year, which were his first post-season starts. He played and started in 15 regular season games in 2011 as the Argonauts missed the playoffs for the third time in four years. During the 2012 Toronto Argonauts season, Van Zeyl started 17 regular season games at right tackle and recorded his first special teams tackle in week 4 against the Winnipeg Blue Bombers. He started in all three post-season games, including the 100th Grey Cup where he earned his first Grey Cup championship in the Argonauts' victory. In 2013, Van Zeyl started 17 regular season games and one playoff game, primarily at right guard, en route to being named a CFL All-Star for the first time in his career. On July 8, 2014, Van Zeyl signed an extension through the 2016 season with the Argonauts. He started in all 17 regular season games that he played in during the 2014 season and was named an East All-Star at offensive tackle. In 2015, he played in only 14 regular season games, starting 13, while also starting the East Semi-Final game. In 2016, he started all 18 regular season games for the first time in his career and was again named an East All-Star at offensive tackle. During the offseason, Van Zeyl signed another contract extension with the Argonauts on January 13, 2017, through to the 2019 CFL season. He played and started in 16 regular season games for the team and was named a CFL All-Star for the second time in his career. He started at right tackle for both post-season games, including his second Grey Cup championship in the Argonauts' 105th Grey Cup victory over the Stampeders. He started 17 games at right tackle in 2018 and was once again named an East Division All-Star. In a reportedly salary cap-related move, the Argonauts released Van Zeyl on the day before the start of training camp on May 18, 2019.
Hamilton Tiger-Cats
On the same day of his Toronto release, the Hamilton Tiger-Cats signed Van Zeyl to a two-year contract on May 18, 2019. He started 17 regular season games and two post-season games for the Tiger-Cats and was named a CFL All-Star for the third time in his career.
