Vázquez attended the Puerto Rico Baseball Academy and High School, and was selected by the Boston Red Sox in the ninth round of the 2008 MLB Draft. His first professional team was the rookie league Gulf Coast Red Sox in 2008 and part of 2009, where he batted 21-for-94 in 31 games. During 2009, he also played 21 games for the Class A Short SeasonLowell Spinners, where he had a.123 average. Vázquez next played two seasons for the Class AGreenville Drive. In 2010, he batted.263 with 3 home runs and 32 runs batted in in 79 games. In 2011, he batted.283 with 18 home runs and 84 RBIs in 105 games. In 2012, he batted a combined.254 with seven home runs and 46 RBIs in a total of 101 games for the Class A-AdvancedSalem Red Sox and the Double-APortland Sea Dogs, compiling a.986 fielding percentage while throwing out a 40% of potential base stealers. In 2013, Vázquez played 96 games for Double-A Portland, batting.289 with five home runs and 48 RBIs; he also played a single game for the Triple-APawtucket Red Sox, going 0-for-3 at the plate. In 2014, Vázquez had a slash line of.275/.331/.715 in his first 62 games for Triple-A Pawtucket, and was named to the International League All-Star team. In addition, he was a late addition to the All-Star Futures Game, but was replaced on the roster due to his promotion to the major leagues on July 9.
Boston Red Sox
;2014 Vázquez made his MLB debut on July 9, starting at catcher against the Chicago White Sox; he was hitless in three at bats, while defensively tagging out a runner at the plate when Alejandro De Aza tried to score from first base on a double by Tyler Flowers. Vázquez recorded his first career hit on July 11, off of the Houston Astros' Scott Feldman; Vázquez had three hits, three RBIs, and scored two runs in the game. His first home run came on September 25, off of Jeremy Hellickson of the Tampa Bay Rays. In 55 games played with the 2014 Red Sox, Vázquez batted.240 with a home run and 20 RBIs. ;2015 On April 2, Vázquez underwent Tommy John surgery and was placed on the 60-day disabled list; he missed the entire season. ;2016 Vázquez split time between Boston and Pawtucket during 2016. He played in 42 Triple-A games, batting.270 with two home runs and 16 RBIs. With the 2016 Red Sox, Vázquez played in 57 MLB games, batting.227 with one home run and 12 RBIs. ;2017 During the 2017 Red Sox regular season, Vázquez batted.290 with five home runs and 32 RBIs; he also had seven stolen bases. He played in 99 games; 95 as catcher, two as designated hitter, and two as third baseman. In an August 1 game at Fenway Park, Vázquez belted a ninth-inning three-run walk-off home run to beat the Cleveland Indians, 12–10, capping a comeback in what some considered to be the best game of the season. The 2017 American League Division Series was the first postseason appearance for Vázquez. He started two of the series' four games, batting 2-for-6, as the Red Sox fell to the eventual World Series champions, the Houston Astros. ;2018 Vázquez started the season as the primary catcher for the 2018 Red Sox, backed up by Sandy León. On July 8, he was placed on the disabled list due to a right fifth finger fracture. At the time, Vázquez was batting.213 for the season, with three home runs and 14 RBIs. On July 10, it was reported that his injury would require surgery in order to insert a pin, and that he would miss six to eight weeks. Vázquez was sent on a rehabilitation assignments with Double-A Portland on August 27, and Triple-A Pawtucket on August 28. He was actived from the disabled list on September 1. Overall for the regular season, he appeared in 80 games, batting.207 with three home runs and 16 RBIs. In the postseason, Vázquez appeared in 12 games, going 8-for-37 at the plate, as the Red Sox won the World Series in five games over the Los Angeles Dodgers. ;2019 Vázquez started the 2019 season as one of two catchers for Boston, along with Blake Swihart, who was later traded. With the 2019 Red Sox, On June 21, Vasquez hit a walk-off two-run home run in the 10th to cap a comeback against the Toronto Blue Jays. Vázquez appeared in a career-high 138 games, batting.276 with 66 runs scored, 26 doubles, 23 home runs and 72 RBIs. He was also a finalist for the Gold Glove catcher, leading all catchers in fielding %
Personal
Vázquez credits his development as a catcher in part to the Molina brothers, who have all played Major League Baseball.
