Cicero Avenue begins at the Governors Highway in University Park. About a mile further north, the road crosses into Cook County from Will County. In Matteson, Cicero Avenue crosses U.S. Route 30. In Country Club Hills, Cicero Avenue passes under Interstate 80 and over Interstate 57, but does not have an interchange with either highway. About a mile further north than Interstate 57, the road intersects U.S. Route 6 in Oak Forest. One and one-half miles further, Cicero Avenue intersects Illinois Route 83. The two routes run concurrent for two and one-half miles, from Midlothian to Alsip. At their northern split in Alsip, Cicero Avenue also has an interchange with Interstate 294. In Oak Lawn the street intersects U.S. Route 12/U.S. Route 20. One mile further north, at 87th Street, Cicero Avenue enters the city of Chicago. For one mile from 63rd Street to 55th Street, Cicero Avenue serves as the eastern boundary for Chicago Midway International Airport. Just north of Midway, the road intersects Archer Avenue. Then, Cicero Avenue has an interchange with Interstate 55. Just north of Interstate 55, the road serves as the eastern end for the western segment of 39th Street. Just north of here, the road enters the town of Cicero, for which it is named. In Cicero, the road intersects Ogden Avenue, Cermak Road, and Roosevelt Road. At Roosevelt Road, Cicero Avenue reenters Chicago. Just north of here, the road has an interchange with Interstate 290. North of Interstate 290, Cicero Avenue crosses Madison Street, changing from the south side to the north side. Further north, the road intersects Chicago Avenue and Division Street. It also intersects Illinois Route 64. The next streets that Cicero Avenue intersects are Grand Avenue, Armitage Avenue, Fullerton Avenue, Diversey Avenue, Belmont Avenue, and Addison Street. One-half of a mile further north of Addison Street, Cicero Avenue intersects Milwaukee Avenue and Illinois Route 19. The road then crosses over Interstate 90 and intersects Foster Avenue. Cicero Avenue now has an interchange with Interstate 94. The road then crosses U.S. Route 14. Cicero Avenue now leaves the city of Chicago and enters Lincolnwood, where it intersects Devon Avenue and Touhy Avenue. Cicero Avenue becomes Skokie Boulevard at Jarvis Avenue as it enters Skokie. At Lincoln Avenue, in Skokie, Illinois Route 50 ends, and U.S. Route 41 continues on Cicero Avenue. While still in Skokie, the road intersects Howard Street and the eastern end of Illinois Route 58. Skokie Boulevard finally ends at Interstate 94 in Wilmette. U.S. Route 41 continues north onto the expressway.
