Molina auditioned for Univision's reality show and beauty pageant Nuestra Belleza Latina 2015 in New York City on October 4, 2014. Judge Jomari Goyso and guest judges Daniel Arenas and Veronica Bastos did not give her a pass to enter the competition due to them seeing her as arrogant. Days later head judge Osmel Sousa went to her home in New Jersey to personally invite her to be part of the competition. After several eliminations, she was selected to be part of the 12 finalists who enter the mansion of Nuestra Belleza Latina where she became a favorite among both the judges and audience. After 13 weeks of competition, she made it to the Top 4 and finished as 3rd Runner-Up. The eventual winner was Francisca Lachapel of the Dominican Republic.
After Clarissa had finished competing in Nuestra Belleza Latina Clarrisa competed in Miss Dominican Republic 2015 representing the province of Espaillat where she was eventually crowned the winner, earning the right to represent the country at the 2015 Miss Universe pageant.
Miss Universe 2015
Clarissa represented the Dominican Republic at Miss Universe 2015 where she competed to succeed outgoing titleholder Paulina Vega of Colombia, eventually finished in the Top 10. A later evaluate give her the 6th place. The eventual winner was Pia Wurtzbach of the Philippines.
NBL VIP 2016 - Nuestra Belleza Latina 2016
In 2016, Clarissa Molina was chosen by the production of Nuestra Belleza Latina to compete in Nuestra Belleza Latina 2016. The season was referred to as "NBL VIP" and was the shows first All Star season, consisting of twenty-six returning non-winning/runner up contestants representing the shows nine seasons for a second chance to win the title. On May 22, 2016, after 6 weeks of competition Clarissa Molina was crowned as Nuestra Belleza Latina 2016, making her the second Dominican to obtain the title, after Francisca Lachapel in 2015. Clarissa and Francisca's wins made the Dominican Republic the first nation to obtain crowns in two consecutive years. Clarissa's win also ties the Dominican Republic and Mexico for the second most wins, each nation obtaining two crowns. She is also the second winner to have been born in the 1990s after Marisela de Montecristo.
Her dream was always to be a Hollywood star, and in 2018 she got her wish. Molina starred the Dominican movie Que Leon, accompanied by the reggaeton artist Ozuna. The movie is about how a relationship blooms between two people with different social statuses.
