Combretastatin A-1
Combretastatin A-1 is a combretastatin and a stilbenoid. It can be found in Combretum caffrum, the Eastern Cape South African Bushwillow tree.It is an antiangiogenic agent acting by destabilizing tubulin, which induces cell apoptosis of proliferating endothelial cells.Currently designated an orphan drug by the FDA, combretastatin A1 diphosphate is in Phase I clinical trials for relapsed and refractory acute myeloid leukemia and myelodysplastic syndrome.
