In 1685, the Constantia estate was established in a valley facing False Bay by the Governor of the Cape, Simon van der Stel whose "Constantia wyn" soon acquired a good reputation. But it was Hendrik Cloete, who bought the homestead in 1778, who really made Constantia famous, with an unfortified wine made from a blend of mostly Muscat de Frontignan, Pontac, red and white Muscadel and a little Chenin Blanc. It became a favorite of European kings and emperors, such as Frederick the Great and Napoleon who had it ordered from his exile on St Helena. In 1861, however, the Gladstone government removed empire preferential tariffs, and as a result exports nearly dried up, and the golden era was brought to an end when the vineyards were decimated by phylloxera and powdery mildew, In 1980 Duggie Jooste bought Klein Constantia, redeveloped the farm, and with the help of then winemaker Ross Gower & Professor Chris Orferr of Stellenbosch University created and began selling a new recreated version of the early Constantia wines made from Muscat Blanc à Petits Grains which they called Vin de Constance. The wine that is produced at Groot Constantia is called Grand Constance, "1769" at Buitenverwachting and "Vin de Constance" at Klein Constantia.
In Sense and Sensibility, Jane Austen's character Mrs Jennings recommends a glass of "the finest old Constantia wine" for the broken-hearted Marianne, on the grounds that it helped her late husband's colicky gout; Elinor, though amused by the incongruity, still drinks the wine to try "its healing powers on a disappointed heart" – her own.
In Charles Dickens' last novel, The Mystery of Edwin Drood, Constantia wine is served to the reverend Septimus by his mother. "As, whenever the Reverend Septimus fell a-musing, his good mother took it to be an infallible sign that he ‘wanted support,’ the blooming old lady made all haste to the dining-room closet, to produce from it the support embodied in a glass of Constantia and a home-made biscuit."
In Charles Baudelaire's Les fleurs du mal poem XXVI entitled Sed non satiata Baudelaire compares the charms of his beloved to the pleasures brought by Nuits-Saint-Georges and Constantia wine: "Even more than Constantia, than opium, than Nuits, I prefer the elixir of your mouth, where love performs its slow dance."
In Brad Thor's The Lions of Lucerne the wine plays a prominent role. It provides a major clues which helps the lead character Scot Harvath to unravel a plot.
In Joris-Karl Huysmans' decadent novel, A rebours, the protagonist, Floressas Des Esseintes, extols the virtues of Constantia wine and takes some in an attempt to alleviate a weak stomach.
In Patrick O'Brian's Post Captain, the second book in his Aubrey-Maturin series of historical novels set during the Napoleonic Wars, Jack Aubrey attends a party at which Constantia wine forms part of the buffet.