Contryphan
The contryphans are a family of peptides that are active constituents of the potent venom produced by cone snail. The two amino acid cysteine residues in contryphans are linked by a disulfide bond. In addition, contryphans undergo an unusual degree of post-translational modification including
epimerization of leucine and tryptophan, tryptophan bromination, amidation of the C-terminus, and proline hydroxylation. In the broader scheme of genetic conotoxin classification, contryphans are members of "Conotoxin Superfamily O2."Family members
Contryphan family members include:
| Peptide | Sequence | Species | Reference |
| Descontryphan-R | COwEPWC-NH2 | C. radiatus | |
| Contryphan-R | GCOwEPWC-NH2 | Conus radiatus | |
| Bromocontyphan-R | GCOwEPXC-NH2 | C. radiatus | |
| Contryphan-Sm | GCOwQPWC-NH2 | Conus stercusmuscarum | |
| Contryphan-P | GCOwDPWC-NH2 | C. purpurascens | |
| Contryphan-R/Tx | GCOwEPWC-NH2 | Conus textile | |
| Contryphan-Tx | GCOWQPYC-NH2 | Conus textile | |
| Contryphan-Vn | GDCPwKPWC-NH2 | Conus ventricosus | |
| Leu-contryphan-P | GCVlLPWC-OH | Conus purpurascens | |
| Leu-contryphan-Tx | CVlYPWC-NH2 | Conus textile | |
| Glaconryphan-M | NγSγCPWHPWC-NH2 | Conus marmoreus | |
where the sequence abbreviations stand for:
and the remainder of the letters refer to the standard one letter abbreviations for amino acids.Mechanism of toxicity
The venom of cone snails cause paralysis of their fish prey. The molecular target has not been determined for all contryphan peptides, however it is known that contryphan-Vn is a Ca2+-dependent K+ channel modulator, while glacontryphan-M is a L-type calcium channel blocker.
