Clement attended and played college football at the University of Wisconsin from 2013–2016. Clement played in 12 games as a true freshman. As a backup to James White and Melvin Gordon during the 2013 season, he rushed for 547 yards on 67 carries with seven touchdowns. As a sophomore in 2014, he again was the backup to Gordon. Behind Gordon in 2014, Clement had 147 carries for 949 rushing yards and nine touchdowns; 14 receptions for 119 receiving yards and two touchdowns. The 2015 season was the first year where Clement was Wisconsin's featured running back after Melvin Gordon elected to declare for the 2015 NFL Draft following his redshirt junior season. Just prior to the first game of the season against Alabama in Dallas, Clement injured his groin. Throughout the game against Alabama, Clement was sparingly used, with 8 carries for 16 yards and 2 receptions for 19 yards. He missed the next two games, against Miami and Troy, with the groin injury before it was announced that he would miss a further four to six weeks after he would receive a sports hernia surgery. He was projected to be able to play in the last three games of the regular season with his first game back being November 7 against Maryland. In late September, Clement traveled to Munich, Germany for his sports hernia surgery, which would be performed by renowned specialist Ulrike Muschaweck. In limited action, he had 221 rushing yards and five rushing touchdowns in four games in the 2015 season. The 2016 season was the best of Clement's collegiate career statistically. In the first three games, against LSU, Akron, and Michigan State, he totaled 251 rushing yards and five rushing touchdowns. On October 15, against Ohio State, he had 164 rushing yards, and one week later, he had 134 rushing yards and a touchdown against Iowa. On November 12, against Illinois, he had 123 rushing yards and three rushing touchdowns. In the Big Ten Conference Championship game against Penn State, he had 164 rushing yards and a touchdown in the 38–31 loss. Overall, he finished his final collegiate season with 1,375 rushing yards, 15 rushing touchdowns, 12 receptions, and 132 receiving yards.
On May 11, 2017, Clement signed with the Philadelphia Eagles as an undrafted free agent. He was active in his first NFL game against the Washington Redskins on September 10, 2017. On September 24, 2017, Clement scored his first NFL touchdown against the New York Giants on a 15-yard run. In Week 9, against the Denver Broncos, Clement had a breakout day with 12 rushes for 51 yards, two rushing touchdowns, and a 15-yard touchdown reception. Overall, he finished his rookie season with 321 rushing yards, four rushing touchdowns, 10 receptions, 123 receiving yards, and two receiving touchdowns. The Philadelphia Eagles finished with a 13–3 record and earned a first-round bye. In the against the Atlanta Falcons, he had 31 receiving yards in the 15–10 victory. In the against the Minnesota Vikings, he had 20 rushing yards in the 38–7 victory. During Super Bowl LII against the New England Patriots, Clement finished with 8 rushing yards on 3 carries and 100 receiving yards on 4 receptions plus a touchdown as the Eagles won 41–33, giving them their first Super Bowl win in franchise history. He also took the snap of the Philly Special which he handed off to Trey Burton, who in turn threw a touchdown pass to quarterback Nick Foles.
Clement returned to the Eagles in the 2018 season to a very crowded backfield. He scored his first touchdown of the 2018 season in Week 2 against the Tampa Bay Buccaneers. He was placed on injured reserve on December 11, 2018 after suffering a knee injury in Week 14. He finished the 2018 season with 259 rushing yards and two rushing touchdowns.
Clement played mostly on special teams in the first four games of the 2019 season before he was placed on injured reserve with a shoulder injury on October 11, 2019. The Eagles chose not to place a restricted free agent tender on Clement following the 2019 season, and he became a free agent on March 18, 2020.
2020 season
Despite not being tendered by the Eagles as a restricted free agent, on April 29, he re-signed with the team on a one-year deal.
