Cullen's sign


Cullen's sign is superficial edema and bruising in the subcutaneous fatty tissue around the umbilicus.
It is named for gynecologist Thomas Stephen Cullen, who first described the sign in ruptured ectopic pregnancy in 1916.
This sign takes 24–48 hours to appear and can predict acute pancreatitis, with mortality rising from 8–10% to 40%. It may be accompanied by Grey Turner's sign, which may then be indicative of pancreatic necrosis with retroperitoneal or intra-abdominal bleeding.

Causes

Causes include:
Importance of the sign is on a decline since better diagnostic modalities are now available.