In 2011, Kouandjio contributed as a true freshman, playing in eight games until a knee injury in the second half against Tennessee ended his season. As a sophomore in 2012, Kouandjio started all 14 games at the left tackle position. He had the least number of career starts on the Alabama offensive line in the 2012 season. In the 2013 BCS National Championship Game against Notre Dame, Alabama repeatedly ran to the left behind Kouandjio, contributing to 265 net yards rushing and 5.9 yards per rush. On Alabama's third drive, Kouandjio pancake blocked Notre Dame defensive end Sheldon Day. Kouandjio ended the 2012 season ranked as the top offensive tackle from the 2011 recruiting class. As a junior in 2013, Kouandjio was a first-team All-Southeastern Conference selection. After the season, he decided to forego his senior season and entered the 2014 NFL Draft.
Professional career
As early as April 2013, Kouandjio was projected as one of the top selections in the 2014 NFL Draft.
Buffalo Bills
Kouanjio was drafted by the Buffalo Bills in the second round of the 2014 NFL Draft. He became the fifth Alabama offensive lineman selected in the first two rounds in six years, after Andre Smith, James Carpenter, Chance Warmack, and D. J. Fluker. Kouandjio suffered an ankle injury near the start of the 2016 season, causing him to miss multiple weeks. He went on to play 12 games with five starts in 2016. On January 26, 2017, Kouandijo suffered a hip injury after falling in his home and underwent surgery. He was expected to recover in time for training camp. On May 24, 2017, Kouandijo was released by the Bills.
On November 8, 2017 Kouandjio was signed by the Denver Broncos. He played in three games, starting one at right tackle in 2017. On September 1, 2018, Kouandjio was released by the Broncos. He was re-signed on November 20, 2018. He was released again on December 4, 2018. Kouandjio was drafted in the 2nd round in phase two in the 2020 XFL Draft by the New York Guardians.
Saskatchewan Roughriders
On March 23, 2020, Kouandjio signed with the Saskatchewan Roughriders of the Canadian Football League.
Personal life
Kouandjio's older brother, Arie, played at Alabama and plays offensive guard for the Washington Redskins. Cyrus is married to his college girlfriend, Elizabeth Van Zandt who was also an athlete at the University of Alabama. On April 20, 2017, Kouandjio was found undressed by deputies and firefighters in Elma, New York. Kouandjio required medical attention in an undisclosed condition, and was granted first-aid. Kouandjio formally turned himself in, avoiding his arrest.