DCHS1


Protein dachsous homolog 1, also known as protocadherin-16 or cadherin-19 or cadherin-25 or fibroblast cadherin-1, is a protein that in humans is encoded by the DCHS1 gene.

Function

This gene is a member of the cadherin superfamily whose members encode calcium-dependent cell-cell adhesion molecules. The encoded protein has a signal peptide, 27 cadherin repeat domains and a unique cytoplasmic region. This particular cadherin family member is expressed in fibroblasts but not in melanocytes or keratinocytes. The cell-cell adhesion of fibroblasts is thought to be necessary for wound healing.

Clinical significance

Mutations in this gene have been shown to cause mitral valve prolapse