DCTN2


Dynactin subunit 2 is a protein that in humans is encoded by the DCTN2 gene

Function

This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 23 subunits. The subunit is commonly referred to as p50 or dynamitin. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that bind to two copies of p150-glued and two copies of p24 to form the dynactin shoulder domain.

Interactions

DCTN2 has been shown to interact with MARCKSL1.