Audick was drafted by the Pittsburgh Steelers in the 1977 NFL draft. He started in 33 of 76 regular season games while playing for the St. Louis Football Cardinals, the San Diego Chargers, and the San Francisco 49ers. In post-season play, Audick started in 5 of 6 playoff games. Under the leadership of Coach Don Coryell, Audick played on a Chargers' team that clinched two consecutive playoff berths. With the 1980 San Diego Chargers, Audick started at the right tackle position in the game versus the Oakland Raiders where he protected Dan Fouts' frontside in the "Air Coryell" offense. In 1981, Audick was traded to the San Francisco 49ers. Though he was considered to be "undersized" for the left tackle position, he was tasked with the responsibility of protecting Joe Montana's "blindside." Under the guidance of Coach Bill Walsh, Audick was a key contributor on the final 89-yard drive that led to the play that has been immortalized as "The Catch" in the versus the Dallas Cowboys. Audick subsequently started in Super Bowl XVI wearing number 61 for the 49ers' 26-21 victory over the Cincinnati Bengals. When Michael Lewis's was researching for his 2006 book,, he called upon several former NFL coaches and players who had played the left tackle position including Audick. Audick helped Lewis understand the role of the "undersized" versus the "prototypical." In Lewis's book, Audick is credited with having played a contributing role in the evolution of the "undersized" left tackle position. In 2009, the book was made into a movie called The Blind Side. Audick was the first student athlete to graduate from the University of Hawaii and to contribute to a winning Super Bowl team. Dan was the defensive line coach in 1991 for Grossmont College in El Cajon, California.
In addition to his professional football career, Audick pursued three advanced degrees in the field of Sports Administration. Subsequent to his NFL retirement, he completed his MBA at San Diego State University in 1986. In honing his studies to Sports Administration, he crafted his coursework and thesis toward the design and development of a computerized feedback system for college and professional football teams. It was not until 2006 that SDSU formally graduated the official first class for a Sports MBA program . Audick was also an early participant in Internet education when he earned his second master's degree at the University of Phoenix's online program from 1994 to 1996. Audick completed his education by earning a doctorate in education in the field of Human Performance Technology at the University of Southern California. For his Ed.D dissertation, Audick used an instructional design enhancement to augment the instruction and communication of offensive passing routes and formations as compared with traditional approaches by using "eight points of a compass" coupled with measurable distances down field and a "grid and code" system, respectively.
