Sarginson made his début for Harlequins and scored a try in the 70-0 victory over Gateshead Thunder in the Challenge Cup match at Gateshead International Stadium on Friday 6 May 2011, and made his Super League début for Harlequins and scored two tries in the 18-26 defeat by Salford City Reds at The Willows, Salford on Friday 1 July 2011. Sarginson was offered a four year contract by London Broncos in 2012 but refused to sign the deal. After this he was injured on-and-off for the majority of his time in London and went on to play just 51 times for the capital Super League side, scoring 17 tries. On 18 October 2013, Wigan Warriors announced that they had signed the out-of-contract Sarginson for the 2014 and 2015 Super League seasons.
On 29 March 2016, Sarginson announced that he would leave the Super League, and join the National Rugby League club, Gold Coast Titans for the 2017 and 2018 seasons. He made six appearances for Gold Coast during the 2017 NRL season before suffering a season-ending shoulder injury.
Return to Wigan
On 13 December 2017, Gold Coast Titans agreed to release Sarginson who had made few appearances and faced a court case in his time in Australia. Wigan Warriors re-signed Sarginson on a two-year deal. On his return he was handed the number 3 shirt vacated by Anthony Gelling. After starting in the first two matches of the season he missed the next two months with a recurrence of a shoulder injury which restricted his appearances whilst at the Gold Coast Titans. On his return to the team he scored his first try of the season against the Catalans Dragons before missing a months of action with an ankle injury a few weeks later. A try against Hull FC was followed a week later by another injury ruling him out for another month before his return to the side against St Helens. A try against the Castleford Tigers and a brace against St Helens followed as he found some of the form which helped the Warriors lift the Super League trophy in 2016. After a resounding victory over St Helens he received the news that his younger brother had died, as the Wigan club gathered around him, he decided to play just days later against Wakefield Trinity. After an emotional minutes silence Sarginson helped defeat Wakefield to keep Wigan's unbeaten run going. He played in the 2018 Super League Grand Final victory over the Warrington Wolves at Old Trafford.
International career
He was part of the England squad for the 2014 Four Nations tournament. Sarginson was selected in England's 24-man squad for the 2016 Four Nations.
