Christened Daniela Garnero, Santanchè was born in Cuneo, Piedmont. She moved to Turin to study political science, and at 21 married Paolo Santanchè, a plastic surgeon. She was employed by his company in an administrative role. After studying political science, in 1983 she founded a company that focused on marketing. She later acquired shares of the Billionaire company, along with Flavio Briatore, Lele Mora, Paolo Brosio and Marcello Lippi. In 1995, she left her husband, Paolo Santanchè, and began a relationship with Canio Mazzaro, a pharmaceutical entrepreneur from Potenza. Her marriage to Paolo Santanchè was declared void by the Roman Rota. In politics she has continued to use the Santanchè surname, despite an unsuccessful court case by her ex-husband to try to stop her. Her current partner is the journalist Alessandro Sallusti, editor of il Giornale, a daily newspaper owned by Paolo Berlusconi and Vittorio Feltri.
Santanchè held the position of chief of the department for equal opportunity for the National Alliance from 2005 to 2007. In 2005, Santanchè was harshly criticised when she showed her middle finger, in a gesture of insult, towards a student protest against the Moratti school reform. In 2005, Santanchè was nominated to hold the discussion of the annual Financial Law, the first woman in Italian history in such a role. In 2006, she was re-elected to the Italian Chamber of Deputies with National Alliance in the constituency of Milan. On 22 October 2006, while she was participating in a live show, "Controcorrente", to discuss matters regarding the Islamic veil, Santanchè was criticized by the Imam of Segrate. The prefect of Milan stated that her safety was at risk and he would consider the possibility of taking security measures to protect her.
''La Destra'' (2008)
More than a year later, on 10 November 2007, Daniela Santanchè resigned from the National Alliance party to join Francesco Storace's new party The Right. The same day, she was appointed official speaker for the party Santanchè was then the Prime Minister candidate for The Right in the 2008 Italian general election. Along with Flavia D'Angeli and Fabiana Stefanoni, she was the first woman to be a candidate for Italian prime minister. The Right did not acquire the necessary share of votes to enter the Parliament and Daniela Santanchè therefore ended her parliamentary mandate. After seven years as deputy, she received €65,534 as termination indemnities '', and €3,605 monthly as lifetime allowance. She declared that she will donate this to charity.
''Movimento per l'Italia'' (2008–10)
On 28 September 2008, after arguing with party secretaryFrancesco Storace, Santanchè left the party. Shortly afterwards, with Diego Zarneri and other former La Destra politicians, she founded the Movement for Italy political movement, in order to come closer to Silvio Berlusconi's People of Freedom. On 20 September 2009, she appeared with Diego Zarneri at the Eid ul-Fitrreligious holiday in Milan. According to Muslims, Santanchè tried to unveil some women, causing a reaction by local men. In her version, Santanchè says she asked the police to apply Italian law, which bans appearing in public with a veil, and that she made no contact with a Muslim woman. Afterwards, she declared she had been assaulted and beaten, but this was denied by Muslim eyewitnesses. At the hospital, she was examined and found to have chest bruises, that would take 20 days to heal. On 25 September on the il Fatto Quotidiano newspaper, a short video shot by peacereporter seems to disprove any alleged assault on Santanchè. In the video, Santanchè is shown trying to cross the police barrier, while no assault on her is shown. Santanchè's lawyers dismissed the video as a fabrication, releasing a copy of the reports by the hospital and by the police.
Diploma Scandal of 2011
On 22 March 2011, the magazine Oggi published an article stating that although on her resume Santanchè claimed to have an MBA from the Bocconi University, the university itself had no record of having awarded her any such degree. Santanchè did not resign, claimed she was telling the truth and threatened to sue the magazine for libel. No evidence of her degree has turned up, although it appears that she did attend another, unspecified, course at the university.