Lowry was born to Margaret and John Lowry and attended Boylan Central Catholic High School in Rockford, Illinois. Besides football, he lettered in baseball as a freshman and played basketball for one year. He was part of two undefeated teams. He was named as a SuperPrep All-Midwest honoree and an All-State selection by both the Chicago Tribune and Champaign-News Gazette. He finished his senior year with 65 tackles, and 10 sacks. Lowry was ranked as the 34th defensive end in the country and the 17th best prospect in the state of Illinois. He was ranked as a three star recruit and received a number of scholarship offers from schools such as Northwestern, Ball State, Illinois State, Indiana, Iowa, Northern Illinois, Purdue, Vanderbilt, and Western Michigan. He committed to Northwestern on June 7, 2011.
College career
Lowry ultimately elected to take the scholarship offer of Northwestern and played in all 13 games that year as a backup to future Minnesota Vikings defensive end Tyler Scott. During a game against Vanderbilt, he had one fumble recovery, one quarterback hurry, two solo tackles, and a pass deflection on the line of scrimmage. His efforts that year earned him ESPN.com Big Ten All-Freshman Team honors. Going into his second season with the Wildcats, Lowry started nine games at defensive end. While making his first start against Syracuse, he had his first career interception. He missed the game against Nebraska to injury, however he did have his first career touchdown on an interception return against Maine. During a game against Ohio State, he had six tackles and recovered a fumble. He finished the year second on the team in tackles for loss with seven, and third on the team with 4.5 sacks. Lowry started every game at defensive end in his junior season. During a game against Notre Dame, he recorded six tackles and forced a fumble. During a game against Western Illinois, Lowry moved over to the defensive tackle spot and had four tackles, one sack, and two passes defensed. He was named the Defensive Player of the Game as a result of his performance. He was named to the Academic All-Big Ten team and an honorable mention by league coaches. He finished his junior year with 41 tackles with 8 for a loss, ranking second on the team. In his final year with the team, Lowry set a single-game team record against Nebraska with six tackles for a loss, he also recorded two sacks in the game and was named the team's Defensive Player of the Game. He again picked up that honor in a game against the Duke Blue Devils where he had six tackles with half of one for a loss. He was named as a consensus pick to the second team All-Big Ten team.
Professional career
Lowry was predicted to be a seventh round pick or signed immediately as an undrafted free agent by Lance Zierlein. Zierlein cited that he had a good burst off the offensive line and kept his pads at the correct level. He also stated that he was built physically to be in a 3–4 defense and that he had a good work ethic and "team-first" mentality. However, he was concerned about his short arms and small hands that prevented him from winning on the line of scrimmage, and that he was not as active at finding the ball as he should be. He also mentioned that he did not excel at pass rushing. Overall, Zierlein believed that he would be drafted and most likely become a backup at the professional level. Dane Bugler of CBS Sports commented that Lowry was "heavy-handed" and used his momentum and size to compete against blockers and that he played to the best of his ability on every play. He also cited concerns about his lack of explosiveness and pass-rush moves. He also believed he would be a backup in the NFL. Lowry was selected in the fourth round of the 2016 NFL Draft with the second of two compensatory picks. Rob Demovsky, a staff writer for ESPN, commented that he was surprised that general manager Ted Thompson ignored the offense this far in the draft. He also mentioned that the Packers liked his athleticism. Eliot Wolf, president of the Green Bay Packers football operations, said in the regards to his pick that he believed Lowry was "an underrated athlete". On May 6, 2016, he signed a contract with the Packers. Lowry recorded his first NFL sack against the Houston Texans on December 4, 2016. He also recorded a deflected pass and a handful of tackles in that game. On December 3, 2017, in a 26–20 victory over the Tampa Bay Buccaneers, Lowry recovered a Jameis Winston fumble and returned it for the first touchdown in his career in the NFL. Lowry was awarded NFC Defensive Player of the Week for this performance. On July 23, 2019, Lowry signed a three-year, $20.325 million contract extension with the Packers. In week 15 of the 2019 season against the Chicago Bears, Lowry recorded his first career interception off a pass thrown by Mitch Trubisky during the 21–13 win.
