A primary application of defoliants is the selective killing of plants. Two of the oldest chemical herbicides used as defoliants are 2,4-Dichlorophenoxyacetic acid and 2,4,5-Trichlorophenoxyacetic acid. 2,4-D and 2,4,5-T are absorbed by broad-leafed plants, killing them by causing excessive hormonal growth. These phenoxy herbicides were designed to selectively kill weeds and unwanted plants in croplands. They were first introduced at the beginning of World War II and became widespread in use in agriculture following the end of the War. Defoliants have a practical use in the harvesting of certain crops, particularly cotton, in the United States as well as a number of other cotton-producing countries. The use of defoliants aids in the effective harvesting of cotton and finer lint quality. The effectiveness of defoliant use in cotton harvesting depends on the type of defoliant used, the number of applications, the amount applied, and environmental variables. Common harvest-aiding chemical defoliants include tribufos, dimethipin, and thidiazuron. According to a 1998 report by the U.S. Department of AgricultureNational Agricultural Statistics Service, tribufos and thidiazuron accounted for 60% of crop area that was treated by defoliants during that crop year.
Health and environmental effects
In 1998, the U.S. Environmental Protection Agency concluded that the use of agricultural defoliants led to increased risks of water contamination and dangers to freshwater and marine life. High doses of tribufos were labeled as a possible carcinogen and a toxin to freshwater and marine invertebrates. Dimethipin has also been labeled as a possible human carcinogen. A published study in the Journal of Agricultural and Food Chemistry reported that through successive surface runoff events in defoliated cotton fields, defoliant concentrations decreased exponentially within the test area and could negatively affect marine life in the runoff zones. Agent Orange, a defoliant used by the United Kingdom during the Malayan Emergency in the 1950s and the United States during the Vietnam War to defoliate regions of Vietnam from 1961 to 1971, has been linked to several long-term health issues. Agent Orange contains a mixture of 2,4-D and 2,4,5-T as well as dioxin contaminants. Members of the Air ForceRanch Hand and the Army Chemical Corps who served in the Vietnam War were occupationally exposed to Agent Orange have a higher incidence of diabetes, heart disease, hypertension, and chronic respiratory diseases. Among other occupations, farmers are at a significantly higher risk of developing Alzheimer's disease due to a greater chance of defoliant exposure.