The borough has a total area of, of which is land and is water. The borough contains North America's highest point: Denali, from which it derives its name, at 6190.5 m.
At the 2000 census there were 1,893 people, 785 households, and 452 families residing in the borough. The population density was 0.148 people per square mile. There were 1,351 housing units at an average density of 0.106 per square mile. The racial makeup of the borough was 85.74% White, 1.43% Black or African American, 4.75% Native American, 1.53% Asian, 0.37% Pacific Islander, 0.95% from other races, and 5.23% from two or more races. 2.48%. were Hispanic or Latino of any race. Of the 785 households 31.00% had children under the age of 18 living with them, 48.40% were married couplesliving together, 4.50% had a female householder with no husband present, and 42.30% were non-families. 35.00% of households were one person and 1.40% were one person aged 65 or older. The average household size was 2.28 and the average family size was 3.03. The age distribution was 23.80% under the age of 18, 6.70% from 18 to 24, 36.80% from 25 to 44, 29.70% from 45 to 64, and 3.10% 65 or older. The median age was 38 years. For every 100 females, there were 139.00 males. For every 100 females age 18 and over, there were 147.10 males. Denali Borough is the 63rd highest-income county in the United States, and highest-income county in Alaska, by personal per capita income as of 2009.
In the Twilight Saga by Stephenie Meyer, the Denali vampire coven lives in Denali because of the lack of sunlight. The film Into the Wild, based on a book of the same name, featured a bus where Christopher McCandless died became a destination for film fans. The 1940s bus was taken to a remote trail about 60 years ago by a road crew, according to Denali Borough Mayor, Clay Walker. Visitors to the site had to cross the Teklanika River. In 2019 a newlywed Belarusian woman drowned trying to cross the swollen river on her way to the site. Another drowning took place in 2010. A stranded Brazilian had to be rescued in April 2020 and five Italians were rescued in February 2020, with one suffering from severe frostbite. In total 15 bus-related search and rescue operations for visitors to the bus were carried out between 2009 and 2017. In June 2020 the bus was removed because of public safety concerns. It was air-lifted by a US army Chinook helicopter. Alaskan authorities are quoted as saying the bus would be kept in a "secure location" until a decision is made about its future. Clay Walker said, "It is part of our history and it does feel a little bittersweet to see a piece of our history go down the road."
