Denis Duboule is a Swiss-French biologist. He earned his PhD in Biology in 1984 and is currently Professor of Developmental Genetics and Genomics at the École polytechnique fédérale de Lausanne and at the Department of Genetics and Evolution of the University of Geneva. Since 2001, he is the Director of the Swiss National Research Center "Frontiers in Genetics" and since 2017, he is also a professor at the Collège de France. He has notably worked on Hox genes, a group of genes involved in the formation of the body plan and of the limbs.
Biography
Denis Duboule obtained a PhD from the University of Geneva in 1984. After questioning Karl Illmensee's claims of having cloned a mouse, Duboule departed to work as a post-doc and then a group leader at the University of Strasbourg, with Pierre Chambon. In 1988, he became a group leader at the European Molecular Biology Laboratory in Heidelberg, Germany. In 1992, he obtained a tenure at the Geneva University. From 1997, he has headed the Department of Genetics and Evolution Since 2001, he has also chaired the NCCR Frontiers in Genetics and, since 2006, he is a full professor at the École polytechnique fédérale de Lausanne. In 2017, he was elected professor at the Collège de France, holding the international chair in genome evolution and development. He is a Fellow of the Royal Society. and a member of the National Academy of Sciences He is also an occasional columnist in the "Sciences and environment" section of the newspaper Le Temps.
Scientific contributions
Denis Duboule has a longstanding interest in the function and regulation of Hox genes, a family of genes responsible for the organization and evolution of animal body plans. These genes have been a paradigm to understand embryonic patterning, in developmental, evolutionary and pathological contexts. Denis Duboule's contributions are thus in the field of vertebrate developmental genetics with some interface with medical genetics and evolutionary biology. Since 1985, he reported several discoveries related to the biology of homeobox genes, in particular concerning the Hox gene family. A brief account can be found in the article "The Hox complex"
