Quiñones won the Miss Universe 2001 pageant in Bayamon, Puerto Rico in 2001. She was crowned by Lara Dutta, Miss Universe 2000 of India and also won the awards of Miss Photogenic, Bluepoint Swimsuit, and Clairol Best Style. She is only the fourth Miss Universe winner to also win Miss Photogenic after Margareta Arvidsson, Margarita Moran, and Janelle Commissiong. Her win came on the Miss Universe pageant's 50th anniversary. As Miss Universe, Quiñones resided in New York City for a year, enjoying the benefits that all winners of the pageant receive, including complimentary make-up and haircare, a car, complete wardrobe, professional representation by the Miss Universe Organization, a $60,000 scholarship to a New York Cityfilm school, and traveling opportunities. Quiñones was the first winner to wear the reputed Mikimoto Crown during its official press presentation by Mikimoto’s former brand director, Mr. Toyohiko Miyamoto. On the night of the Miss Universe 2002 contest, she passed on her crown, once again in Puerto Rico, to Oxana Fedorova of Russia. Since relinquishing the title, Quiñones attended the School for Film and Television's two-year conservatory acting program. Presently an actress, Quiñones has starred in the Spanish version of Nilo Cruz's play Ana en el trópico and continues to hone her talent in the United States. For her role in Anna in the Tropics, she was nominated and awarded an HOLA Award and an ACE Award. In October 2005, she was selected for the role of Doña Rosita, in a production of Federico García Lorca's play Doña Rosita la soltera. Quiñones guest-starred in a season 5 episode of the WB Network television series Smallville. She played Andrea, a masked avenger who fought crime in Metropolis and invited Clark Kent to join her in her adventures. On the heels of her Smallville role, she was also cast in the role of "Rachel", a young fighter pilot in the pilot for the TV seriesAquaman, which was in development for the CW Television Network. The pilot did not make the fall 2006 lineup. In November 2006, Quiñones led the off-Broadway cast of Zanahorias, a Spanish comedy by Spanish playwright Antonio Zancada. For her role in Zanahorias, she won an ACE Award in 2007. In July 2008, it was announced that Quiñones would play the part of Lara in the upcoming film I Hope They Serve Beer In Hell, based on the book of the same name. On July 24, 2008, producer Tucker Max announced on the film's official production blog that Quiñones had dropped out due to a scheduling conflict. In February 2014, Quiñones joined the eighth season of Univision's beauty pageant reality show Nuestra Belleza Latina 2014 as a team mentor where she coaches a team of young women on modeling industry success techniques. On February 15, 2018, Quiñones was named as the new pageant director for Miss Universe Puerto Rico, taking over responsibilities previously held by former director Desiree Lowry.
