In June 1902, construction started with grading at Enid, Oklahoma. Track laying began at Enid, reaching Guthrie, Oklahoma, on July 3, 1904. The first passenger train was an excursion train run from Enid to Guthrie on July 4, 1904. 1905 marked completion of the line northward from Enid to Kiowa, Kansas. The line from Guthrie to Kiowa was. The Denver, Enid and Gulf Railroad never reached its expressed terminals. When the Santa Fe acquired it, the line became a connecting link between its south bound Texas line at Guthrie, and its west bound California, Kansas, line at Kiowa. On May 22, 1907, the Denver, Enid and Gulf Railroad was sold to the Eastern Oklahoma Railway. Soon thereafter, on June 20, 1907, it was resold to the Atchison, Topeka and Santa Fe Railway.
Geography
Starting at the south end of the line in Guthrie, Oklahoma, the DE&G departed from the AT&SF mainline just north of downtown and curved northwestward, paralleling, then crossing the sand-choked Cimarron River on a long wooden pile bridge. The line continued northwestward through several small farming communities, servicing grain elevators. A high wooden trestle carried the railroad across Skeleton Creek. At Enid, Oklahoma, the line crossed the former Chicago, Rock Island and Pacific Railroad as well as two lines of the St. Louis-San Francisco Railway. In Enid the former AT&SF brick freight depot houses the Railroad Museum of Oklahoma, across the street from the classic Tudor AT&SF passenger station. Between Jet and Cherokee, Oklahoma, the line crossed the western portion of the salt flats at Great Salt Plains Lake for several miles atop an earth berm fill. North of Cherokee it bridged the Salt Fork of the Arkansas River, including a long wooden trestle over the flood plain. At Kiowa, Kansas, the line terminated at a junction with the current BNSF Railway transcontinental line after passing through a cut about deep.
Passenger Service
In March 1949, Northbound train number 54 left Guthrie at 8:15 AM Central Time, arrived in Enid at 9:55 AM, and terminated in Kiowa at 11:55 AM. Southbound train number 53 departed Kiowa at 12:30 PM, arrived in Enid at 2:30 PM, and terminated in Guthrie at 4:20 PM.
Abandonments
;Blanton, Oklahoma, to Kiowa, Kansas - 1996 ;Guthrie, Oklahoma, to Fairmont, Oklahoma - 1998
Current operations
to Fairmont, Oklahoma, is operated by BNSF Railway for directional running, in tandem with a parallel line which was formerly part of the Frisco. This is now part of BNSF Railway Avard sub, used for transcontinental traffic.
