Desmethylsertraline
Desmethylsertraline, also known as norsertraline, is an active metabolite of the antidepressant drug sertraline. Like sertraline, desmethylsertraline acts as a monoamine reuptake inhibitor, and may be responsible for some of its parent's therapeutic benefits. However, DMS is significantly less potent relative to sertraline as a serotonin reuptake inhibitor, but conversely, is more balanced as a monoamine reuptake inhibitor = 76 nM; NE = 420 nM; DA, which has the effective result of DMS contrarily behaving as a serotonin-norepinephrine-dopamine reuptake inhibitor, with about 5.5-fold preference for inhibiting serotonin reuptake relative to catecholamine reuptake.
Dasotraline, a stereoisomer of DMS, is also an SNDRI, and has been investigated for the potential clinical treatment of major depressive disorder, attention-deficit disorder, and eating disorders, but has not been approved or marketed for any indication.
