Dichloroacetyl chloride
Dichloroacetyl chloride is the organic compound with the formula CHCl2COCl. It is the acyl chloride of dichloroacetic acid. It is a colourless liquid and is used in acylation reactions.Preparation
Unlike typical acid chlorides, dichloroacetyl chloride is not prepared from the acid. Industrial routes include oxidation of 1,1,2-trichloroethane, hydrolysis of pentachloroethane, and the carboxylation of chloroform:Uses
Hydrolysis gives dichloroacetic acid. It is one of the precursors to antibiotics, including chloramphenicol.
Another reported use was in the synthesis of WIN 18,446.
