The show follows the lives of surgical interns and resident doctors of Sanjeevani hospital. It deals with the pressures, drama, romance, inter personal relationships and humour in their lives. At the start of the show the interns are Dr. Anjali Gupta, Dr. Armaan Malik, Dr. Riddhima Gupta, Dr. Atul Joshi, and Dr. Sapna Shah. Dr. Shashank Gupta is head of the hospital, and the father of Anjali and Riddhima. Initially, Armaan and Riddhima were at loggerheads. Anjali and Armaan becomes good friends and Riddhima, Atul and Sapna becomes good friend. A medical camp is arranged in a village where Armaan and Riddhima comes closer towards each other. Slowly, they become friends. Riddhima comes to know that she is Nurse Padma's daughter and not Dr. Shashank's real daughter. Anjali makes a bet with Armaan that Riddhima will fall for him. Riddhima comes to know about this. She is heartbroken. After few instances, they resolve their differences and Riddhima finally confesses her love to Armaan. They are enjoying their togetherness. Two new interns enter: Dr Rahul Garewal and Dr Muskaan Chadda. Rahul and Armaan have a tashan between them. Muskaan likes Armaan and Rahul likes Riddhima. Meanwhile, Atul started liking Anjali and Sapna gets married with a patient. Rahul and Muskaan's family wants them to get married but they don't want to. To get away from this situation, Muskaan takes help from Armaan without telling Riddhima about this. This leads to separation between Armaan and Riddhima. Rahul now knows about them. Nurse Padma and Dr Shashank gets married. Dr Shubhanker likes Dr Keerti. Riddhima and Armaan becomes friends again and eventually they confess again marking their togetherness. On the other side, Muskaan and Rahul develops feelings for each other. Dr Nikita Malhotra joins Sanjeevani. Nikita turns out to be Armaan's and Rahul's college friend who is secretly in love with Armaan. Dr Abhimanyu Modi enters Sanjeevani to save it from financial crisis. He makes some decisions which were not accepted by the interns. They do non-cooperation movement and arrange a special show to collect funding. Dr Abhimanyu develops feelings for Dr Riddhima first. All the friends doubt that Armaan and Riddhima are together. So, they ask Nikita's help. But Nikita helps Armaan instead in keeping the secret and they all think Armaan and Nikita have a scene instead of Riddhima. Armaan thinks of impressing Dr Shashank so he disguises himself and changes his looks into a soft, simple person. Riddhima is pissed off because of this. Armaan arranges a special date for her. Unfortunately, police catches them and everyone comes to know about them. No one allows them to meet each other. Armaan takes help from all the friends to persuade Dr Shashank and Anjali who are against their relationship. He starts living outside their house in a tent. Media started to publicize this matter. Finally on valentines day, Dr. Shashank gives in due to Ridhhima's deteriorating health and accepts them,"Dr.Love" gets his love and Armaan Riddhima comes together. Their roka is planned. Armaan's family comes. Billy is very frank which Dr Shashank doesn't like. Billy and Annie were separated and Dr Shashank wants to dig out this matter. Armaan Riddhima started to have differences on this. Dr keerti and Shubhanker gets married. Here comes Bubbly, Sister of Dr Shubhanker who gets very frank with Armaan which is not liked by Riddhima. Due to Dr Abhimanyu and Bubbly, Armaan Riddhima have constant fights. One day, Armaan had an accident and he lost his recent memory including Riddhima. Riddhima is heart broken. Armaan makes fun of her unknowingly that she is her life, Riddhima. Armaan have to re write medical exam. She helps him. Both comes closer. Friends try to tell Armaan how much he loved her. They both are together again. They are about to get engaged. On the day of engagement, a pregnant couple tries to hide in the hospital. Big politicians were involved in the case. Armaan and Riddhima are also stuck in the situation. In the last scene of the first season, Riddhima is shot and she falls over Armaan who hits a glass table. Atul is also shot. Dr Abhimanyu estranged wife Jiah returns. The show then takes a leap of some time introducing 5 new interns: Dr. Siddhant Modi, Dr. Yuvraj Oberoi, Dr. Naina Mehta, Dr. Tamanna Patil, and Dr. Jitendra Prasad. Dr. Siddhant Modi falls in love with Riddhima and then they eventually shared some romantic moments until the return of Dr. Armaan. Dr. Shilpa falls in love with Dr. Armaan. But decided to sacrifice her love after knowing that Dr. Riddhima is her step sister. Now Riddhima is in dilemma between Armaan and Siddhant. But when she came to know that Armaan left her because of his disease and that she shouldn't suffer because of him she eventually chooses Armaan and the show ends with Riddhima singing a song for Armaan.
