Diphthamide
Diphthamide is a post-translationally modified histidine amino acid found in archaeal and eukaryotic elongation factor 2.Structure
Diphthamide is proposed to be a 2-3-carboxyamido-3-propyl histidine. Though this structure has been [confirmed by X-ray crystallography, its stereochemistry is uncertain.Diphthamide ensures translation fidelity.
The presence or absence of diphthamide is known to affect NF-κB or death receptor pathways.Biosynthesis
Diphthamide is biosynthesized from histidine and S-adenosyl methionine.
