Douglas R. Green


Douglas Green, is an American biologist. He holds the Peter C. Doherty Endowed Chair of Immunology in St. Jude Children's Research Hospital. His research has focused on the process of active cell death and cell survival, extending from the role of cell death in cancer regulation and immune responses in the whole organism to the molecular events directing the death of the cell. Green was editor in chief of the journal Oncogene from 2009-2016, is a Deputy Editor of the journal "Science Advances" and the author of the book Cell Death, Means To An End.

Education

Green attended high school in Ashland, MA. He graduated magna cum laude from the Yale University with a Bachelor of Science in Biology and Distinction in Biology in 1977. After training at MIT during 1977 and 1978, he graduated in 1981 with a PhD from Yale University, where he studied immunology with Richard K. Gershon.
Green joined the faculty at the University of Alberta in Edmonton in 1985.. In 1990, Green moved to the La Jolla Institute for Allergy and Immunology, where he became Head of the Division of Cellular Immunology. In 2005, he moved to St. Jude Children's Research Hospital to become the Peter C. Doherty Endowed Chair of the Department of Immunology.

Research

After many studies on immunological tolerance, Green's work on cell death began with his discovery of activation-induced apoptosis in T lymphocytes, the role of c-Myc in this process and the finding that Bcl-2 cooperates with Myc in oncogenesis by blocking apoptosis. More recently, he discovered the process of LC3-associated phagocytosis, which links the autophagy pathway to phagosome maturation. Other areas of interest include regulated necrosis, metabolic reprogramming in T lymphocytes, and the function of the tumor suppressor, p53. As of 2014 he had published many chapters and books and over 500 papers, making him one of the world's most cited molecular biologists. He is listed in:
Green has received many awards, among these the E.J. Boell Award , the J.S. Nicholas Award , Alberta Heritage Scholar, the Outstanding Teacher Award, Ashland Public School System Hall of Fame, MERIT Award, NIGMS, the International Cell Death Society Prize, Einstein Professorship. He is an Honorary Fellow of Trinity College, Dublin and Dottore Honoris Causa of Rome University Tor Vergata Green was elected to the Royal Society of Canada in 2018 and the United States National Academy of Sciences in 2020.