The region of Dryinopolis is located on the valley of Drino river. In it came under the control of the Bulgarian army of Samuel, but Byzantine control was restored at 1018/1019. As part of the Byzantine Empire Dryinopolis formed a minor theme during the reign of Emperor Basil II. Basil also established a garrison there under the command of a strategos. According to the history of John Skylitzes, the creation of the theme of Dryinopolis, as well as of nearby Koloneia, and the settlement there of Byzantine prisoners of the Bulgarian army aimed at the strengthening of the Byzantine positions in Epirus against future enemy attacks from central and western Macedonia. The Bulgarian threat temporarily vanished after the annexation of the First Bulgarian Empire. After the sack of Constantinople by the Crusaders in 1204, the region came under the control of the Despotate of Epirus, a Greek successor state of the Byzantine Empire. Dryinopolis formed one of the themes of the Despotate. During the late 14th century Dryinopolis was contested between the Despotate of Epirus and the Albanian Zenebishi clan. In 1399 the Greek population of Dryinopolis joined the Despot of Epirus, Esau, in his campaign against various Albanian and Aromanian tribesmen. Prior to the Ottoman conquest of the region in 1418, it was controlled by John Zenebishi.
Ecclesiastical diocese
Byzantine period
The bishopric of Dryinopolis was already established at 449 AD and its bishop participated in the proceedings of the Ecumenical Council of Ephesus. It was initially under the jurisdiction of the Metropolis of Nicopolis, while later it was a suffragan of the Metropolis of Ioannina. Its seat was initially located in Adrianoupolis on the Drino Valley. After its destruction by the Ostrogoths of Totila in the 6th century, it was transferred to nearby Episkopi. In it was part of the Archbishopric of Ohrid. In 1185 after the destruction of the town of Episkopi by the Normans, the seat was moved to Gardiq in Cepo region and in early 15th century it was transferred to Argyrokastron.
Ottoman period
The menaion of the bishopric records that a number of Sipahi soldiers were registered by the Ottomans in the region during the first decades of Ottoman rule. In the same period, according to a local chronicle, Islamization attempts and massacres were perpetrated by the Ottoman units which stopped after the Fall of Constantinople to the Ottomans. During the prelacy of bishop Dositheos a total of 70 churches were erected and extensively repaired. The bishopric of Dryinopolis was part of the metropolis of Ioannina under the jurisdiction of the Ecumenical Patriarchate of Constantinople. In 1832 it was merged with the nearby Diocese of Cheimarra and in 1835 it was promoted to a metropolitan bishopric.