Roquemore played college football at Texas A&I. While there he was a three-year starter for the Javelinas and was named an All-American in 1980 and 1981. During his career he intercepted a school record 22 passes, including 10 his junior year, which was second in the nation. He was inducted into the schools Hall of Fame in 2000.
Roquemore was drafted by the Kansas City Chiefs in the sixth round of the 1982 NFL Draft. He played two seasons for the Chiefs, starting 3 of 24 games, recording five interceptions for 134 yards and a touchdown.
After spending 1986 out of football, Roquemore came out of retirement to play for the Chicago Bruisers of the Arena Football League. He finished the season recording 35tackles and two interceptions.
Buffalo Bills
Roquemore returned to the National Football League in 1987 during that year's player's strike to play for the Buffalo Bills. During the season, he started two of five games for the Bills.
Second stint with Bruisers
Roquemore returned to the Bruisers in 1988. Roquemore had a strong season, recording 72 tackles, 11 interceptions and a touchdown.
In 1990 Roquemore played for the Albany Firebirds of the AFL. During the season, he had 30 tackles and seven interceptions.
Orlando Predators
Roquemore joined the Orlando Predators in 1991, and would become one of the best players in AFL history. In six years with the Predators he recorded 290 tackles, and 30 interceptions.
Retirement
After the 1996 season Roquemore retired from professional football. He finished his AFL career with 427 tackles, 50 interceptions, and a touchdown. In 1996, he was selected to the Arena Football Leagues Tenth Anniversary Team and in 1999 he was elected to the Arena Football League Hall of Fame. He has the distinction of being the only player in Arena Football League history to be named First-Team All Arena five times. In 2012, during the AFL's 25th anniversary, the league named Roquemore the 21st greatest player in Arena Football League history. In 1997 Roquemore was hired to be the defensive coordinator for the Albany Firebirds and was hired for the same position by the Houston Thunderbirds in 1998 and 1999. In 1999, he became the head coach for the Richmond Speed and remained until 2000.