E2F1
Transcription factor E2F1 is a protein that in humans is encoded by the E2F1 gene.Function
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionarily conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins, a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.E2F1 promoter => E2F1Interactions
E2F1 has been shown to interact with:
- ARID3A,
- CUL1,
- Cyclin A1,
- Cyclin A2,
- GTF2H1,
- MDM4,
- NCOA6,
- NDN,
- NPDC1,
- PURA,
- PHB,
- RB1,
- RBL1,
- SKP2,
- SP1,
- SP2,
- SP3,
- SP4,
- TFDP1
- TOPBP1,
- TP53BP1, and
- UBC.
